Article
EDARV370A associated facial characteristics in Uyghur population revealing further pleiotropic effects.
Human genetics - 1 Jan 2016
Peng Qianqian, Li Jinxi, Tan Jingze, Yang Yajun, Zhang Manfei, Wu Sijie, Liu Yu, Zhang Juan, Qin Pengfei, Guan Yaqun, Jiao Yi, Zhang Zhaoxia, Sabeti Pardis C, Tang Kun, Xu Shuhua, Jin Li, Wang Sijia
Abstract excerpt
An adaptive variant of human Ectodysplasin receptor, EDARV370A, had undergone strong positive selection in East Asia. In mice and humans, EDARV370A was found to affect ectodermal-derived characteristics, including hair thickness, hair shape, active sweat gland density and teeth formation. Facial characteristics are also largely ectodermal derived. In this study, taking advantage of an admixed population of East...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.