Article

Knocking-out the human face genes <i>TBX15</i> and <i>PAX1</i> in mice alters facial and other physical morphology

2021-05-26

Abstract excerpt

DNA variants in or closed to the human TBX15 and PAX1 genes have been repeatedly associated with facial morphology in independent genome-wide association studies, while their functional roles in determining facial morphology remains to be understood. We generated Tbx15 knockout ( Tbx15 -/- ) and Pax1 knockout ( Pax1 -/- ) mice by applying the one-step CRISPR/Cas9 method. A total of 75 adult mice were used...

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Literature Corpus work: ca3fa827-fb6e-5b03-a449-33b012f34957
DOI: 10.1101/2021.05.26.445773

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