Article
South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication.
Retrovirology - 24 Jun 2015
Richardson Simone I, Gray Elin S, Mkhize Nonhlanhla N, Sheward Daniel J, Lambson Bronwen E, Wibmer Constantinos Kurt, Masson Lindi, Werner Lise, Garrett Nigel, Passmore Jo-Ann S, Karim Quarraisha Abdool, Karim Salim S Abdool, Williamson Carolyn, Moore Penny L, Morris Lynn
Abstract excerpt
BACKGROUND: The integrin α4β7 mediates the trafficking of immune cells to the gut associated lymphoid tissue (GALT) and is an attachment factor for the HIV gp120 envelope glycoprotein. We developed a viral replication inhibition assay to more clearly evaluate the role of α4β7 in HIV infection and the contribution of viral and host factors. RESULTS: Replication of 60 HIV-1 subtype C viruses collected over time...
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