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Article

Envelope Glycoprotein Binding to the Integrin α <sub>4</sub> β <sub>7</sub> Is Not a General Property of Most HIV-1 Strains

10 Jul 2014

Abstract excerpt

UNLABELLED: The HIV-1 surface glycoprotein gp120 has been reported to bind and signal through α4β7 by means of a tripeptide motif in the V2 loop that mimics structures present in the natural ligands for α4β7, suggesting that α4β7 may facilitate HIV-1 infection of CD4(+) T cells in the gut. Furthermore, immune correlates in the RV144 vaccine efficacy trial generated the hypothesis that V1V2 antibodies to an...

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PMID: 25008916
DOI: 10.1128/jvi.03296-13

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Envelope Glycoprotein Binding to the Integrin α <sub>4</sub> β <sub>7</sub> Is Not a General Property of Most HIV-1 StrainsPMID 25008916Read ↗

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