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Article

Conservation of the α4β7 lymphocyte homing receptor in HIV-infected patients with distinct transmission routes and disease progression profiles.

AIDS research and human retroviruses - 1 May 2014

Hait Sabrina H, Darc Mirela, Machado Elizabeth S, Soares Esmeralda A, Sprinz Eduardo, Soares Marcelo A

Abstract excerpt

The α4β7 is a lymphocyte homing receptor to the gut-associated lymphoid tissue (GALT). HIV-1 gp120 binds to α4β7 integrin through a mimetic tripeptide in V2 and ensures successful infection of GALT. In the present report, we investigated the presence of polymorphisms in the α4β7 cytoplasmic and α4 N-terminal binding domains and their potential association with susceptibility to HIV infection or disease...

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Source

Identifiers

PMID: 24387749
DOI: 10.1089/AID.2013.0248

Genes

GALT
ITGA4
ITGB7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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