Article
The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmission.
PLoS pathogens - 1 Feb 2011
Nawaz Fatima, Cicala Claudia, Van Ryk Donald, Block Katharine E, Jelicic Katija, McNally Jonathan P, Ogundare Olajumoke, Pascuccio Massimiliano, Patel Nikita, Wei Danlan, Fauci Anthony S, Arthos James
Abstract excerpt
Mucosal transmission of HIV is inefficient. The virus must breach physical barriers before it infects mucosal CD4+ T cells. Low-level viral replication occurs initially in mucosal CD4+ T cells, but within days high-level replication occurs in Peyer's patches, the gut lamina propria and mesenteric lymph nodes. Understanding the early events in HIV transmission may provide valuable information relevant to the...
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