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Article

Influence of HIV-1 V2 sequence variability on bacterial translocation in antiretroviral naïve HIV-1 infected patients.

Journal of medical virology - 1 Dec 2020

Balena Flavia, Bavaro Davide F, Volpe Anna, Lagioia Antonella, Angarano Gioacchino, Monno Laura, Saracino Annalisa

Abstract excerpt

HIV-1 V2 domain binds α4β7, which assists lymphocyte homing to gut-associated lymphoid tissue. This triggers bacterial translocation, thus contributing to immune activation. We investigated whether variability of V2 179-181 binding site could influence plasma levels of lipopolysaccharide (LPS) and soluble cluster of differentiation 14 (sCD14), markers of microbial translocation/immune activation. HIV gp120...

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PMID: 32609386
DOI: 10.1002/jmv.26246

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