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Article

Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals.

PLoS pathogens - 1 Jan 2014

Pickering Suzanne, Hué Stephane, Kim Eun-Young, Reddy Susheel, Wolinsky Steven M, Neil Stuart J D

Abstract excerpt

The HIV-1 Vpu protein is expressed from a bi-cistronic message late in the viral life cycle. It functions during viral assembly to maximise infectious virus release by targeting CD4 for proteosomal degradation and counteracting the antiviral protein tetherin (BST2/CD317). Single genome analysis of vpu repertoires throughout infection in 14 individuals infected with HIV-1 clade B revealed extensive amino acid...

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PMID: 24465210
DOI: 10.1371/journal.ppat.1003895
PMCID: PMC3900648

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BST2

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Preservation of tetherin and CD4 counter-activities in circulating Vpu alleles despite extensive sequence variation within HIV-1 infected individuals.PMID 24465210Read ↗

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