Article
RNA ligation in neurons by RtcB inhibits axon regeneration.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 2015
Kosmaczewski Sara Guckian, Han Sung Min, Han Bingjie, Irving Meyer Benjamin, Baig Huma S, Athar Wardah, Lin-Moore Alexander T, Koelle Michael R, Hammarlund Marc
Abstract excerpt
Activity of the RNA ligase RtcB has only two known functions: tRNA ligation after intron removal and XBP1 mRNA ligation during activation of the unfolded protein response. Here, we show that RtcB acts in neurons to inhibit axon regeneration after nerve injury. This function of RtcB is independent of its basal activities in tRNA ligation and the unfolded protein response. Furthermore, inhibition of axon...
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