Article

Local translation is engaged to sustain synaptic function in impaired Wallerian degeneration

2023-08-20

Abstract excerpt

After injury, the severed axon separated from the soma activates programmed axon degeneration, an evolutionarily conserved pathway to initiate its degeneration within a day. Conversely, severed projections deficient in programmed axon degeneration remain morphologically preserved with functional synapses for weeks to months after injury. How this synaptic function is sustained remains currently unknown. Here, we d...

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Literature Corpus work: 7ca045da-bff4-502c-8645-14cb1d01b4ce
DOI: 10.1101/2023.08.18.553870

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