Article

Axon-seq decodes the motor axon transcriptome and its modulation in response to ALS

2018-05-14

Abstract excerpt

<h4>SUMMARY</h4> Spinal motor axons traverse large distances to innervate target muscles, thus requiring local control of cellular events for proper functioning. To interrogate axon-specific processes we developed Axon-seq, a refined method incorporating microfluidics, RNA-seq and bioinformatic-QC. We show that the axonal transcriptome is distinct from somas and contains fewer genes. We identified 3,500-5,000 tra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b2b4d854-3a12-5aef-8bfb-0607b0c961c9
DOI: 10.1101/321596

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Axon-seq decodes the motor axon transcriptome and its modulation in response to ALSDOI 10.1101/321596Read

Axon-Seq Decodes the Motor Axon Transcriptome and Its Modulation in Response to ALSSemantic proximity Read

Unraveling Axonal Transcriptional Landscapes: Insights from iPSC-Derived Cortical Neurons and Implications for Motor Neuron DegenerationSemantic proximity Read

Deep axonal proteomics of human iPSC-derived neurons by microfluidic separation and DIA-MSSemantic proximity Read

A multi-omics characterization reveals distinct molecular signatures in the human motor cortex and lumbar spinal cord in ALSSemantic proximity Read

RNA-seq analysis of skeletal muscle in motor neurone disease cases and controlsSemantic proximity Read

ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS modelsSemantic proximity Read

Whole blood transcriptome profile identifies motor neurone disease (MND) RNA biomarker signaturesSemantic proximity Read

Axonal mRNA in human embryonic stem cell derived neuronsSemantic proximity Read

Dysregulation of synaptogenesis genes antecedes motor neuron pathology in spinal muscular atrophySemantic proximity Read

Whole blood transcriptome profile identifies motor neurone disease RNA biomarker signaturesSemantic proximity Read

An emergent disease-associated motor neuron state precedes cell death in a mouse model of ALSSemantic proximity Read

Spatial transcriptomics identifies dysregulated programs across neural and non-neural tissues in spinal muscular atrophySemantic proximity Read