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Article

Mutational analysis of MED12 in fibroadenomas and phyllodes tumors of the breast by means of targeted next-generation sequencing.

Breast cancer research and treatment - 1 Jul 2015

Mishima Chieko, Kagara Naofumi, Tanei Tomonori, Naoi Yasuto, Shimoda Masafumi, Shimomura Atsushi, Shimazu Kenzo, Kim Seung Jin, Noguchi Shinzaburo

Abstract excerpt

We aimed to analyze MED12 mutation in fibroadenomas (FAs) and phyllodes tumors (PTs) of the breast, which are closely related and consist of epithelial and stromal components. Targeted deep-sequencing using next-generation sequencing was performed in FAs (n = 58) and PTs (n = 27). The frequency of MED12 mutant tumors was significantly higher (P = 0.016) in PTs (74.1 %) than in FAs. (46.6 %). As for FAs, this...

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Source

Identifiers

PMID: 26093648
DOI: 10.1007/s10549-015-3469-1

Genes

MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutational analysis of MED12 in fibroadenomas and phyllodes tumors of the breast by means of targeted next-generation sequencing.PMID 26093648Read ↗

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