Article
Genomic landscapes of breast fibroepithelial tumors.
Nature genetics - 1 Nov 2015
Tan Jing, Ong Choon Kiat, Lim Weng Khong, Ng Cedric Chuan Young, Thike Aye Aye, Ng Ley Moy, Rajasegaran Vikneswari, Myint Swe Swe, Nagarajan Sanjanaa, Thangaraju Saranya, Dey Sucharita, Nasir Nur Diyana Md, Wijaya Giovani Claresta, Lim Jing Quan, Huang Dachuan, Li Zhimei, Wong Bernice Huimin, Chan Jason Yong Sheng, McPherson John R, Cutcutache Ioana, Poore Gregory, Tay Su Ting, Tan Wai Jin, Putti Thomas Choudary, Ahmad Buhari Shaik, Iau Philip, Chan Ching Wan, Tang Anthony P H, Yong Wei Sean, Madhukumar Preetha, Ho Gay Hui, Tan Veronique Kiak Mien, Wong Chow Yin, Hartman Mikael, Ong Kong Wee, Tan Benita K T, Rozen Steven G, Tan Patrick, Tan Puay Hoon, Teh Bin Tean
Abstract excerpt
Breast fibroepithelial tumors comprise a heterogeneous spectrum of pathological entities, from benign fibroadenomas to malignant phyllodes tumors. Although MED12 mutations have been frequently found in fibroadenomas and phyllodes tumors, the landscapes of genetic alterations across the fibroepithelial tumor spectrum remain unclear. Here, by performing exome sequencing of 22 phyllodes tumors followed by targeted...
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