Article
Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis.
Genes, chromosomes & cancer - 1 Jul 2015
Pfarr Nicole, Kriegsmann Mark, Sinn Peter, Klauschen Frederick, Endris Volker, Herpel Esther, Muckenhuber Alexander, Jesinghaus Moritz, Klosterhalfen Bernd, Penzel Roland, Lennerz Jochen K, Weichert Wilko, Stenzinger Albrecht
Abstract excerpt
Somatic mutations in exon 2 of MED12 have been described in benign and malignant smooth muscle cell tumors suggesting a functional role in these neoplasms. Recently fibroadenomas of the breast were also reported to harbor MED12 mutations. Hence, we explored MED12 mutations in fibroepithelial tumors of the breast, histological subtypes of fibroadenomas and phyllodes tumors, to validate and extend previous efforts....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.