Article
Ablation of the scaffold protein JLP causes reduced fertility in male mice.
Transgenic research - 1 Dec 2008
Iwanaga Asuka, Wang Guangmin, Gantulga Davaakhuu, Sato Tokiharu, Baljinnyam Tuvshintugs, Shimizu Keiko, Takumi Ken, Hayashi Motoharu, Akashi Takuya, Fuse Hideki, Sugihara Kazushi, Asano Masahide, Yoshioka Katsuji
Abstract excerpt
The specific and efficient activation of mitogen-activated protein kinase (MAPK) signaling modules is mediated, at least in part, by scaffold proteins. c-Jun NH(2)-terminal kinase (JNK)-associated leucine zipper protein (JLP) was identified as a scaffold protein for JNK and p38 MAPK signaling modules. JLP is expressed nearly ubiquitously and is involved in intracellular signaling pathways, such as the G(alpha13)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.