Article
Ggnbp2-Null Mutation in Mice Leads to Male Infertility due to a Defect at the Spermiogenesis Stage.
The American journal of pathology - 1 Nov 2017
Liu Lingyun, He Yan, Guo Kaimin, Zhou Linying, Li Xian, Tseng Michael, Cai Lu, Lan Zi-Jian, Zhou Junmei, Wang Hongliang, Lei Zhenmin
Abstract excerpt
Gametogenetin binding protein 2 (GGNBP2) is an evolutionarily conserved zinc finger protein. Although Ggnbp2-null embryos in the B6 background died because of a defective placenta, 6.8% of Ggnbp2-null mice in the B6/129 mixed background were viable and continued to adulthood. Adult Ggnbp2-null males were sterile, with smaller testes and an azoospermic phenotype, whereas mutant females were fertile....
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