Article
A nonsense mutation in mouse Adamtsl2 causes uterine hypoplasia and an irregular estrous cycle.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Dec 2023
Iwanaga Yuka, Tsuji Kaori, Nishimura Ayaka, Tateishi Kouji, Kakiuchi Misa, Tsuji Takehito
Abstract excerpt
The spontaneous mutation stubby (stb) in mice causes chondrodysplasia and male infertility due to impotence through autosomal recessive inheritance. In this study, we conducted linkage analysis to localize the stb locus within a 1.6 Mb region on mouse chromosome 2 and identified a nonsense mutation in Adamtsl2 of stb/stb mice. Histological analysis revealed disturbed endochondral ossification with a reduced...
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