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Article

Strong association of de novo copy number mutations with sporadic schizophrenia.

Nature genetics - 1 Jul 2008

Xu Bin, Roos J Louw, Levy Shawn, van Rensburg E J, Gogos Joseph A, Karayiorgou Maria

Abstract excerpt

Schizophrenia is an etiologically heterogeneous psychiatric disease, which exists in familial and nonfamilial (sporadic) forms. Here, we examine the possibility that rare de novo copy number (CN) mutations with relatively high penetrance contribute to the genetic component of schizophrenia. We carried out a whole-genome scan and implemented a number of steps for finding and confirming CN mutations. Confirmed de...

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PMID: 18511947
DOI: 10.1038/ng.162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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