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Article

Phenotypically distinct subtypes of psychosis accompany novel or rare variants in four different signaling genes.

EBioMedicine - 1 Apr 2016

Kranz Thorsten M, Berns Adam, Shields Jerry, Rothman Karen, Walsh-Messinger Julie, Goetz Raymond R, Chao Moses V, Malaspina Dolores

Abstract excerpt

BACKGROUND: Rare gene variants are important sources of schizophrenia vulnerability that likely interact with polygenic susceptibility loci. This study examined if novel or rare missense coding variants in any of four different signaling genes in sporadic schizophrenia cases were associated with clinical phenotypes in an exceptionally well-characterized sample. METHOD: Structured interviews, cognition, symptoms...

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Source

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Identifiers

PMID: 27211562
DOI: 10.1016/j.ebiom.2016.03.008
PMCID: PMC4856793

Genes

PTPRG
TGM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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