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Article

Functional Role of the C-Terminal Amphipathic Helix 8 of Olfactory Receptors and Other G Protein-Coupled Receptors.

International journal of molecular sciences - 18 Nov 2016

Sato Takaaki, Kawasaki Takashi, Mine Shouhei, Matsumura Hiroyoshi

Abstract excerpt

G protein-coupled receptors (GPCRs) transduce various extracellular signals, such as neurotransmitters, hormones, light, and odorous chemicals, into intracellular signals via G protein activation during neurological, cardiovascular, sensory and reproductive signaling. Common and unique features of interactions between GPCRs and specific G proteins are important for structure-based design of drugs in order to...

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PMID: 27869740
DOI: 10.3390/ijms17111930
PMCID: PMC5133925

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