Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amino-acid changes acquired during evolution by olfactory receptor 912-93 modify the specificity of odorant recognition.

Human molecular genetics - 1 Apr 2004

Gaillard Isabelle, Rouquier Sylvie, Chavanieu Alain, Mollard Patrice, Giorgi Dominique

Abstract excerpt

The sense of smell in mammals can perceive and discriminate a wide variety of volatile odorants. Odorants bind to specific olfactory receptors (ORs) to initiate an action potential that transduces olfactory information to the olfactory cortex. We previously identified the structural motifs of odorant molecules (aliphatic 2- or 3-ketones) required to activate mouse OR912-93 by detection of the odorant response...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Amino Acids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arginine

Share to Ligands

Share to Odorants

Share to Pongo pygmaeus

Share to Protein Structure, Secondary

Share to Receptors, Odorant

Source

Identifiers

PMID: 14962981
DOI: 10.1093/hmg/ddh086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amino-acid changes acquired during evolution by olfactory receptor 912-93 modify the specificity of odorant recognition.PMID 14962981Read ↗

Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors.Semantic proximity Read ↗

The molecular biology of olfactory perceptionSemantic proximity Read ↗

Encoding of odors by mammalian olfactory receptorsSemantic proximity Read ↗

The sense of smell: genomics of vertebrate odorant receptors.Semantic proximity Read ↗

Amino acid residues contributing to function of the heteromeric insect olfactory receptor complex.Semantic proximity Read ↗

Mutational analysis of cysteine residues of the insect odorant co-receptor (Orco) from Drosophila melanogaster reveals differential effects on agonist- and odorant-tuning receptor-dependent activation.Semantic proximity Read ↗

Evolutionary grass roots for odor recognition.Semantic proximity Read ↗

A gene recently inactivated in human defines a new olfactory receptor family in mammals.Semantic proximity Read ↗

Human olfactory receptor families and their odorants.Semantic proximity Read ↗

Amino acids involved in conformational dynamics and G protein coupling of an odorant receptor: targeting gain-of-function mutation.Semantic proximity Read ↗

Better smelling through genetics: mammalian odor perception.Semantic proximity Read ↗

Structural basis of odorant recognition by a human odorant receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.