IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.

doi:10.1016/j.numecd.2011.05.009

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Article

IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Dec 2012

Yiannakouris N, Cooper J A, Shah S, Drenos F, Ireland H A, Stephens J W, Li K-W, Elkeles R, Godsland I F, Kivimaki M, Hingorani A D, Kumari M, Talmud P J, Humphries S E

Abstract excerpt

BACKGROUND AND AIMS: A recent genome-wide association study identified rs2943641C > T, 500 kb from the insulin receptor substrate-1 gene (IRS1), as a type-2 diabetes (T2D) susceptibility locus. We aimed to replicate this association by meta-analysis and examine whether common variants within IRS1, present on the HumanCVD BeadChip, were associated with T2D risk. METHODS AND RESULTS: We genotyped rs2943641 in 2389...

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Identifiers

PMID: 21917432
DOI: 10.1016/j.numecd.2011.05.009
PMCID: PMC3657179

Genes

IRS1

Variants

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