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Article

Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study.

Atherosclerosis - 1 Jul 2013

Lim Soo, Hong Jaeyoung, Liu Ching-Ti, Hivert Marie-France, White Charles C, Murabito Joanne M, O'Donnell Christopher J, Dupuis Josée, Florez Jose C, Meigs James B

Abstract excerpt

OBJECTIVE: Common variants at the 2q36.3-IRS1 locus are associated with insulin resistance (IR), type 2 diabetes (T2D) and coronary artery disease (CAD) in large-scale association studies. We tested the hypothesis that variants at this locus are associated with subclinical atherosclerosis traits. METHODS: We studied 2740 Framingham Heart Study participants (54.9% women; mean age 57.8 years) with measures of...

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Source

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Identifiers

PMID: 23659870
DOI: 10.1016/j.atherosclerosis.2013.03.037
PMCID: PMC4040123

Genes

IRS1
CAD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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