Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

doi:10.1038/ng.443

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Article

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

Nature genetics - 1 Oct 2009

Rung Johan, Cauchi Stéphane, Albrechtsen Anders, Shen Lishuang, Rocheleau Ghislain, Cavalcanti-Proença Christine, Bacot François, Balkau Beverley, Belisle Alexandre, Borch-Johnsen Knut, Charpentier Guillaume, Dina Christian, Durand Emmanuelle, Elliott Paul, Hadjadj Samy, Järvelin Marjo-Riitta, Laitinen Jaana, Lauritzen Torsten, Marre Michel, Mazur Alexander, Meyre David, Montpetit Alexandre, Pisinger Charlotta, Posner Barry, Poulsen Pernille, Pouta Anneli, Prentki Marc, Ribel-Madsen Rasmus, Ruokonen Aimo, Sandbaek Anelli, Serre David, Tichet Jean, Vaxillaire Martine, Wojtaszewski Jørgen F P, Vaag Allan, Hansen Torben, Polychronakos Constantin, Pedersen Oluf, Froguel Philippe, Sladek Robert

Abstract excerpt

Genome-wide association studies have identified common variants that only partially explain the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from 1,376 French individuals, we identified 16,360 SNPs nominally associated with T2D and studied these SNPs in an independent sample of 4,977 French individuals. We then selected the 28 best hits for replication in 7,698 Danish subjects and...

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Identifiers

PMID: 19734900
DOI: 10.1038/ng.443

Genes

IRS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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