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The type 2 diabetes and insulin-resistance locus near IRS1 is a determinant of HDL cholesterol and triglycerides levels among diabetic subjects.

Atherosclerosis - 1 May 2011

Sharma Rajani, Prudente Sabrina, Andreozzi Francesco, Powers Christine, Mannino Gaia, Bacci Simonetta, Gervino Ernest V, Hauser Thomas H, Succurro Elena, Mercuri Luana, Goheen Elizabeth H, Shah Hetal, Trischitta Vincenzo, Sesti Giorgio, Doria Alessandro

Abstract excerpt

OBJECTIVE: SNP rs2943641 near the insulin receptor substrate 1 (IRS1) gene has been found to be associated with type 2 diabetes (T2D) and insulin-resistance in genome-wide association studies. We investigated whether this SNP is associated with cardiovascular risk factors and coronary artery disease (CAD) among diabetic individuals. METHODS: SNP rs2943641 was typed in 2133 White T2D subjects and tested for...

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Source

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Identifiers

PMID: 21353221
DOI: 10.1016/j.atherosclerosis.2011.01.022
PMCID: PMC3089704

Genes

CAD
IRS1

Variants

rs2943641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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