Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Destabilization of the human epigenome: consequences of foreign DNA insertions.

Epigenomics - 1 Aug 2015

Weber Stefanie, Hofmann Andrea, Herms Stefan, Hoffmann Per, Doerfler Walter

Abstract excerpt

AIM: We previously reported changes of DNA methylation and transcription patterns in mammalian cells that carry integrated foreign DNA. Experiments were now designed to assess the epigenetic consequences of inserting a 5.6 kbp plasmid into the human genome. METHODS: Differential transcription and CpG methylation patterns were compared between transgenomic and nontransgenomic cell clones by using gene chip...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cluster Analysis
Share to CpG Islands
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Epigenomics

Share to HCT116 Cells

Share to Oligonucleotide Array Sequence Analysis

Share to Plasmids

Source

Identifiers

PMID: 26088384
DOI: 10.2217/epi.15.40

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Destabilization of the human epigenome: consequences of foreign DNA insertions.PMID 26088384Read ↗

Characterizing cytosine methylation of polymorphic human transposable element insertions using human pangenome resourcesSemantic proximity Read ↗

Impact of transposable elements on the human genome.Semantic proximity Read ↗

Reconstituting the transcriptome and DNA methylome landscapes of human implantationSemantic proximity Read ↗

Mono-allelic retrotransposon insertion addresses epigenetic transcriptional repression in human genome.Semantic proximity Read ↗

Reprogramming somatic cells into iPS cells activates LINE-1 retroelement mobilitySemantic proximity Read ↗

Hemimethylation and Non-CpG Methylation Levels in a Promoter Region of Human LINE-1 (L1) Repeated ElementsSemantic proximity Read ↗

Frequent lack of repressive capacity of promoter DNA methylation identified through genome-wide epigenomic manipulationSemantic proximity Read ↗

Genome-wide Mapping of PiggyBac Transposon Integrations in Primary Human T CellsSemantic proximity Read ↗

Factors affecting de novo methylation of foreign DNA in mouse embryonic stem cells.Semantic proximity Read ↗

Endogenization and excision of human herpesvirus 6 in human genomesSemantic proximity Read ↗

Genomic alterations in cultured human embryonic stem cells.Semantic proximity Read ↗

Endogenization and excision of human herpesvirus 6 in human genomes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.