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Article

Endogenization and excision of human herpesvirus 6 in human genomes.

PLoS genetics - 1 Aug 2020

Liu Xiaoxi, Kosugi Shunichi, Koide Rie, Kawamura Yoshiki, Ito Jumpei, Miura Hiroki, Matoba Nana, Matsuzaki Motomichi, Fujita Masashi, Kamada Anselmo Jiro, Nakagawa Hidewaki, Tamiya Gen, Matsuda Koichi, Murakami Yoshinori, Kubo Michiaki, Aswad Amr, Sato Kei, Momozawa Yukihide, Ohashi Jun, Terao Chikashi, Yoshikawa Tetsushi, Parrish Nicholas F, Kamatani Yoichiro

Abstract excerpt

Sequences homologous to human herpesvirus 6 (HHV-6) are integrated within the nuclear genome of about 1% of humans, but it is not clear how this came about. It is also uncertain whether integrated HHV-6 can reactivate into an infectious virus. HHV-6 integrates into telomeres, and this has recently been associated with polymorphisms affecting MOV10L1. MOV10L1 is located on the subtelomere of chromosome 22q...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32776928
DOI: 10.1371/journal.pgen.1008915
PMCID: PMC7444522

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