Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1.

The Journal of biological chemistry - 7 Aug 2015

Chang Hao-Yen, Liao Chia-Yu, Su Guan-Chin, Lin Sheng-Wei, Wang Hong-Wei, Chi Peter

Abstract excerpt

DMC1 and RAD51 are conserved recombinases that catalyze homologous recombination. DMC1 and RAD51 share similar properties in DNA binding, DNA-stimulated ATP hydrolysis, and catalysis of homologous DNA strand exchange. A large body of evidence indicates that attenuation of ATP hydrolysis leads to stabilization of the RAD51-ssDNA presynaptic filament and enhancement of DNA strand exchange. However, the functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Monophosphate
Share to Chromosome Pairing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Single-Stranded

Share to Exodeoxyribonucleases

Share to Homologous Recombination

Share to Hydrolysis

Share to Nucleotide Motifs

Share to Rad51 Recombinase

Source

Open in PubMed Open full text

Identifiers

PMID: 26088134
DOI: 10.1074/jbc.M115.666289
PMCID: PMC4528146

Genes

DMC1
RAD51

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional Relationship of ATP Hydrolysis, Presynaptic Filament Stability, and Homologous DNA Pairing Activity of the Human Meiotic Recombinase DMC1.PMID 26088134Read ↗

Mei5-Sae3 stabilizes both active and inactive forms of Dmc1 filaments independently of its impact on ATP hydrolysis.Semantic proximity Read ↗

Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatin.Semantic proximity Read ↗

Biochemical analysis of the human DMC1-I37N polymorphism.Semantic proximity Read ↗

DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfacesSemantic proximity Read ↗

FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombinationSemantic proximity Read ↗

Novel attributes of Hed1 affect dynamics and activity of the Rad51 presynaptic filament during meiotic recombination.Semantic proximity Read ↗

Human RAD51 rapidly forms intrinsically dynamic nucleoprotein filaments modulated by nucleotide binding state.Semantic proximity Read ↗

The translocation activity of Rad54 reduces crossover outcomes during homologous recombinationSemantic proximity Read ↗

CRISPR-dependent base editing screens identify separation of function mutants of RADX with altered RAD51 regulatory activitySemantic proximity Read ↗

Phosphoregulation of RAD51AP1 function in homology-directed repair.Semantic proximity Read ↗

From meiosis to postmeiotic events: Uncovering the molecular roles of the meiosis‐specific recombinase Dmc1Semantic proximity Read ↗

The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restartSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.