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Article

Mei5-Sae3 stabilizes both active and inactive forms of Dmc1 filaments independently of its impact on ATP hydrolysis.

Nucleic acids research - 28 Oct 2025

Chan Yuen-Ling, Reitz Diedre, Budke Brian, Rice Phoebe A, Bishop Douglas K

Abstract excerpt

In budding yeast, Dmc1's recombinogenic activity is controlled by the meiosis-specific heterodimer Mei5-Sae3. Mei5-Sae3 is required for assembly of Dmc1 at sites of meiotic DNA double-stranded breaks. Here, we report Mei5-Sae3 can stabilize Dmc1 filaments in both the active and inactive allosteric conformations depending on the nucleotide cofactor supporting filament formation. Mei5-Sae3 specifically stabilizes...

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PMID: 41206037
DOI: 10.1093/nar/gkaf1085
PMCID: PMC12596195

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