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Article

Biochemical analysis of the human DMC1-I37N polymorphism.

The FEBS journal - 1 Jan 2009

Hikiba Juri, Takizawa Yoshimasa, Ikawa Shukuko, Shibata Takehiko, Kurumizaka Hitoshi

Abstract excerpt

The DMC1 protein, a meiosis-specific DNA recombinase, promotes homologous pairing and strand exchange. The I37N single nucleotide polymorphism of the human DMC1 protein was reported as a result of human genome sequencing projects. In this study, we purified the human DMC1-I37N variant, as a recombinant protein. The DMC1 protein is known to require DNA for efficient ATP hydrolysis. By contrast, the DMC1-I37N...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19076215
DOI: 10.1111/j.1742-4658.2008.06786.x

Genes

DMC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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