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Article

Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling.

The Journal of biological chemistry - 31 Jul 2015

Opel Aaisha, Nobles Muriel, Montaigne David, Finlay Malcolm, Anderson Naomi, Breckenridge Ross, Tinker Andrew

Abstract excerpt

The description of potential molecular substrates for predisposition to atrial fibrillation (AF) is incomplete, and it is unknown what role regulators of G-protein signaling might play. We address whether the attenuation of RGS4 function may promote AF and the mechanism through which this occurs. For this purpose, we studied a mouse with global genetic deletion of RGS4 (RGS4(-/-)) and the normal littermate...

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Source

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Identifiers

PMID: 26088132
DOI: 10.1074/jbc.M115.666719
PMCID: PMC4521044

Genes

RGS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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