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Article

Screening of randomly mutagenized glucagon-like peptide-1 library by using an integrated yeast-mammalian assay system.

Journal of biotechnology - 10 Sept 2015

Shigemori Tomohiro, Kuroda Kouichi, Ueda Mitsuyoshi

Abstract excerpt

Glucagon-like peptide-1 (GLP1) is a 30-amino acid peptide hormone activating the GLP1 receptor (GLP1R), a class B G-protein coupled receptor (GPCR), and is considered to be effective for treating diabetes and other metabolic diseases. Phage display is the first innovative technology in order to prepare and screen a large polypeptide library including GLP1R agonists, but this methodology is not as effective in...

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PMID: 26087314
DOI: 10.1016/j.jbiotec.2015.06.392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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