Article

Isolation of Chemically Cyclized Peptide Binders Using Yeast Surface Display

2020-04-18

Abstract excerpt

Cyclic peptides with engineered protein-binding activity have gained increasing attention for use in therapeutic and biotechnology applications. We describe the efficient isolation and characterization of cyclic peptide binders from genetically encoded combinatorial libraries using yeast surface display. Here, peptide cyclization is achieved by disuccinimidyl glutarate-mediated crosslinking of amine groups within...

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Literature Corpus work: 3abf3eb4-89fc-5957-9150-c8c375f98b0a
DOI: 10.1101/2020.04.16.044438

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