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Article

Generation of designer receptors exclusively activated by designer drugs (DREADDs) using directed molecular evolution.

Current protocols in neuroscience - 1 Jan 2010

Pei Ying, Dong Shuyun, Roth Bryan L

Abstract excerpt

G protein-coupled receptors (GPCRs) and their signal transductions are important for both physiological and pathological processes in neuron systems. Neuronal GPCRs activated by synthetic ligands have been created by designed mutagenesis for studying their functions and signal pathways. However, these engineered GPCRs have problems, such as their high constitutive activity. To overcome this drawback, a new...

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PMID: 20066658
DOI: 10.1002/0471142301.ns0433s50

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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