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Article

Asn384Ser Mutation in Protein C is Associated with Multiple-Site Thrombosis in a Young Heterozygous Male.

Thrombosis and haemostasis - 1 Apr 2026

Yuan Junwei, Zhou Shijie, Wu Xi, Li Fang, Lai Zhe, Ding Qiulan, Wu Wenman, Wang Xuefeng, Dai Jing, Hu Xiaobo, Lu Yeling

Abstract excerpt

Protein C (PC) is an important physiological anticoagulant factor in humans. Activated protein C (APC) is generated from the PC zymogen through proteolytic activation by thrombin. APC inhibits thrombin generation by inactivating activated factors V and VIII via limited proteolysis. In addition to its anticoagulant function, APC also exhibits potent cytoprotective and anti-inflammatory properties. We have...

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Identifiers

PMID: 40250449
DOI: 10.1055/a-2569-6439

Genes

APC
PC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Asn384Ser Mutation in Protein C is Associated with Multiple-Site Thrombosis in a Young Heterozygous Male.PMID 40250449Read ↗

Met343Val mutation disrupts the shuttling of Trp380 leading to a low-activity conformer of activated protein C and causes thrombosis.Semantic proximity Read ↗

Ser252Asn Mutation Introduces a New N-Linked Glycosylation Site and Causes Type IIb Protein C Deficiency.Semantic proximity Read ↗

Gly197Arg mutation in protein C causes recurrent thrombosis in a heterozygous carrier.Semantic proximity Read ↗

Mutation Ter462GlnextTer17 introduces a tail to C-terminus of protein C and causes venous thrombosis.Semantic proximity Read ↗

Analysis of four hereditary protein C deficiencies associated with vascular thromboembolism.Semantic proximity Read ↗

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Thrombomodulin Arg403Lys mutation impairs protein C activation and increases thrombosis risk.Semantic proximity Read ↗

Physiological anticoagulant deficiencies: pathogenesis, diagnosis, and clinical implications.Semantic proximity Read ↗

Analysis of Four Hereditary Protein C Deficiencies Associated with Vascular ThromboembolismSemantic proximity Read ↗

Role of Gly197 in the structure and function of protein C.Semantic proximity Read ↗

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The protein C omega-loop substitution Asn2Ile is associated with reduced protein C anticoagulant activity.Semantic proximity Read ↗

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