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Article

Schlafen2 mutation unravels a role for chronic ER stress in the loss of T cell quiescence.

Oncotarget - 28 Jun 2016

Omar Ibrahim, Lapenna Antonio, Cohen-Daniel Leonor, Tirosh Boaz, Berger Michael

Abstract excerpt

Immunologically naïve lymphocytes are kept in a quiescent state until antigen engagement. These quiescent immune cells are characterized by small cell size, lack of spontaneous proliferation and low metabolic rate. Lymphocyte quiescence is actively enforced condition which ensures the preservation of proper differentiation and proliferation capabilities of naïve and memory lymphocytes. Previously we described a...

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Source

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Identifiers

PMID: 27276683
DOI: 10.18632/oncotarget.9818
PMCID: PMC5129940

Genes

XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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