Article
The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation.
The Journal of biological chemistry - 15 Mar 1996
Chu Y, Solski P A, Khosravi-Far R, Der C J, Kelly K
Abstract excerpt
Mitogen-activated protein (MAP) kinases can be grouped into three structural families, ERK, JNK, and p38, which are thought to carry out unique functions within cells. We demonstrate that ERK, JNK, and p38 are activated by distinct combinations of stimuli in T cells that simulate full or partial...
Topics
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Cycle Proteins
- Cell Line
- Drosophila Proteins
- Dual Specificity Phosphatase 1
- Dual Specificity Phosphatase 2
- Dual-Specificity Phosphatases
- Enzyme Induction
- Female
- HeLa Cells
- Humans
- Immediate-Early Proteins
- JNK Mitogen-Activated Protein Kinases