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Article

Interaction of insulin-like growth factor-I and insulin resistance-related genetic variants with lifestyle factors on postmenopausal breast cancer risk.

Breast cancer research and treatment - 1 Jul 2017

Jung Su Yon, Ho Gloria, Rohan Thomas, Strickler Howard, Bea Jennifer, Papp Jeanette, Sobel Eric, Zhang Zuo-Feng, Crandall Carolyn

Abstract excerpt

PURPOSE: Genetic variants and traits in metabolic signaling pathways may interact with obesity, physical activity, and exogenous estrogen (E), influencing postmenopausal breast cancer risk, but these inter-related pathways are incompletely understood. METHODS: We used 75 single-nucleotide polymorphisms (SNPs) in genes related to insulin-like growth factor-I (IGF-I)/insulin resistance (IR) traits and signaling...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28478612
DOI: 10.1007/s10549-017-4272-y

Genes

AKT1
INS
MAPK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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