Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation landscape of acquired cross-resistance to glycopeptide and β-lactam antibiotics in Enterococcus faecium.

Antimicrobial agents and chemotherapy - 1 Sept 2015

Sacco Emmanuelle, Cortes Mélanie, Josseaume Nathalie, Bouchier Christiane, Dubée Vincent, Hugonnet Jean-Emmanuel, Mainardi Jean-Luc, Rice Louis B, Arthur Michel

Abstract excerpt

Bypass of the d,d-transpeptidase activity of penicillin-binding proteins by an l,d-transpeptidase (Ldtfm) results in resistance to ampicillin and glycopeptides in Enterococcus faecium M9, a mutant obtained by nine consecutive selection steps. Resistance requires activation of a cryptic locus for production of the essential tetrapeptide-containing substrate of Ldtfm and impaired activity of protein phosphatase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to beta-Lactams

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Multiple, Bacterial

Share to Enterococcus faecium

Share to Glycopeptides

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 26077262
DOI: 10.1128/AAC.00634-15
PMCID: PMC4538475

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation landscape of acquired cross-resistance to glycopeptide and β-lactam antibiotics in Enterococcus faecium.PMID 26077262Read ↗

Evolutionary trajectories of β-lactam resistance in Enterococcus faecalis strains.Semantic proximity Read ↗

Evolutionary trajectories of β-lactam resistance in <i>Enterococcus faecalis</i> strainsSemantic proximity Read ↗

Evolution of high-level daptomycin resistance in Enterococcus faecium during daptomycin therapy is associated with limited mutations in the bacterial genome.Semantic proximity Read ↗

Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.Semantic proximity Read ↗

Allele-Specific Effects of Mutations in the Rifampin Resistance-Determining Region (RRDR) of RpoB on Physiology and Antibiotic Resistance in <i>Enterococcus faecium</i>Semantic proximity Read ↗

Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing.Semantic proximity Read ↗

Evolution of peptidoglycan biosynthesis under the selective pressure of antibiotics in Gram-positive bacteria.Semantic proximity Read ↗

Saturation mutagenesis map of generalist versus specialist adaptations of β-lactamase to novel antibioticsSemantic proximity Read ↗

A Daptomycin Resistance-Conferring cls1 I269T Mutation in Enterococcus faecium and its Global Prevalence.Semantic proximity Read ↗

Genetic Basis for Daptomycin Resistance in EnterococciSemantic proximity Read ↗

Genome Modification in Enterococcus faecalis OG1RF Assessed by Bisulfite Sequencing and Single-Molecule Real-Time SequencingSemantic proximity Read ↗

DNA-damaging combination treatments impose genotype-specific constraints on hypermutator evolvabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.