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A Daptomycin Resistance-Conferring cls1 I269T Mutation in Enterococcus faecium and its Global Prevalence.

Current microbiology - 19 Feb 2026

Li Weiwei, Shi Lulu, Hu Jiamin, Zhang Mengge, Sun Yuqing, Wang Wenjia, Li Ling, Xu Hai, Wang Mingyu

Abstract excerpt

Daptomycin is widely considered as a ‘last-resort’ antibiotic used for the treatment of antibiotic-resistant Gram-positive bacteria, including vancomycin-resistant Enterococcus. Resistance to this antibiotic can lead to severe consequences, including inability to find a cure for Gram positive infections. Our previous investigations showed that a mutated cls1 gene mediated low-level daptomycin resistance in...

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PMID: 41711949
DOI: 10.1007/s00284-026-04733-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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