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Article

Evolution of peptidoglycan biosynthesis under the selective pressure of antibiotics in Gram-positive bacteria.

FEMS microbiology reviews - 1 Mar 2008

Mainardi Jean-Luc, Villet Régis, Bugg Timothy D, Mayer Claudine, Arthur Michel

Abstract excerpt

Acquisition of resistance to the two classes of antibiotics therapeutically used against Gram-positive bacteria, the glycopeptides and the beta-lactams, has revealed an unexpected flexibility in the peptidoglycan assembly pathway. Glycopeptides select for diversification of the fifth position of stem pentapeptides because replacement of D-Ala by D-lactate or D-Ser at this position prevents binding of the drugs to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18266857
DOI: 10.1111/j.1574-6976.2007.00097.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evolution of peptidoglycan biosynthesis under the selective pressure of antibiotics in Gram-positive bacteria.PMID 18266857Read ↗

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