Article
Lynch syndrome and cervical cancer.
International journal of cancer - 1 Dec 2015
Antill Yoland C, Dowty James G, Win Aung Ko, Thompson Tina, Walsh Michael D, Cummings Margaret C, Gallinger Steven, Lindor Noralane M, Le Marchand Loïc, Hopper John L, Newcomb Polly A, Haile Robert W, Church James, Tucker Katherine M, Buchanan Daniel D, Young Joanne P, Winship Ingrid M, Jenkins Mark A
Abstract excerpt
Carriers of germline mutations in DNA mismatch repair (MMR) genes are at increased risk of several cancers including colorectal and gynecologic cancers (Lynch syndrome). There is no substantial evidence that these mutations are associated with an increased risk of cervical cancer. A total of 369 families with at least one carrier of a mutation in a MMR gene (133 MLH1, 174 MSH2, 35 MSH6 and 27 PMS2) were...
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