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Article

Gene-specific cancer risks in female Lynch syndrome carriers: A copula-based meta-analysis.

Maturitas - 1 Mar 2026

Karimi Raheleh, Kazemi Iraj, Mansourian Marjan, Marateb Hamid Reza, Mañanas Miquel Angel

Abstract excerpt

BACKGROUND: Lynch syndrome, caused by germline pathogenic variants in mismatch repair genes, markedly increases risks of endometrial, ovarian, and possibly breast cancer in women. We aimed to establish gene-specific risk profiles for these cancers using a unified multivariate model accounting for correlated outcomes. METHODS: Eligible studies reported frequencies of endometrial, ovarian, and breast cancer in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mismatch Repair Endonuclease PMS2

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Source

Identifiers

PMID: 41604823
DOI: 10.1016/j.maturitas.2026.108829

Genes

MSH6
PMS2
MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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