Article

Coexisting germline variants of MLH1 and MSH6 in a patient with Lynch syndrome, endometrial cancer, and ovarian cancer

2024-02-07

Abstract excerpt

<title>Abstract</title> <p>Lynch syndrome is an autosomal dominant disorder caused by a heterozygous pathogenic germline variant in mismatch repair (MMR) genes, including <italic>MLH1</italic>, <italic>MSH2</italic>, <italic>MSH6</italic>, <italic>PMS2</italic>, and <italic>EPCAM</italic>. Lynch syndrome often causes a familial cluster of patients with malignant tumors. We describe a 37-year-old woman who present...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8a3e4b9a-3aae-5ddb-860b-95856f73990f
DOI: 10.21203/rs.3.rs-3926364/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Coexisting germline variants of MLH1 and MSH6 in a patient with Lynch syndrome, endometrial cancer, and ovarian cancerDOI 10.21203/rs.3.rs-3926364/v1Read

Universal screening for Lynch syndrome in endometrial cancers: frequency of germline mutations and identification of patients with Lynch-like syndrome.Semantic proximity Read

New Insights into Lynch Syndrome: A Narrative Review.Semantic proximity Read

Recent advances in Lynch syndromeSemantic proximity Read

Colorectal cancer in Lynch syndrome associated with PMS2 and MSH6 mutations.Semantic proximity Read

Multigene Panel Testing Provides a New Perspective on Lynch Syndrome.Semantic proximity Read

Current clinical topics of Lynch syndrome.Semantic proximity Read

Lynch Syndrome: An Updated ReviewSemantic proximity Read

Lynch Syndrome-associated Genomic Variants.Semantic proximity Read

Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndromeSemantic proximity Read

Review article: the Lynch syndrome (hereditary nonpolyposis colorectal cancer)*Semantic proximity Read

Endometrial and ovarian cancer in women with Lynch syndrome: update in screening and prevention.Semantic proximity Read

Gynecological Cancers Caused by Deficient Mismatch Repair and Microsatellite InstabilitySemantic proximity Read