Article
Childhood cancers in families with and without Lynch syndrome.
Familial cancer - 1 Dec 2015
Heath John A, Reece Jeanette C, Buchanan Daniel D, Casey Graham, Durno Carol A, Gallinger Steven, Haile Robert W, Newcomb Polly A, Potter John D, Thibodeau Stephen N, Le Marchand Loïc, Lindor Noralane M, Hopper John L, Jenkins Mark A, Win Aung Ko
Abstract excerpt
Inheritance of a germline mutation in one of the DNA mismatch repair (MMR) genes or the EPCAM gene is associated with an increased risk of colorectal cancer, endometrial cancer, and other adult malignancies (Lynch syndrome). The risk of childhood cancers in Lynch syndrome families, however, is not well studied. Using data from the Colon Cancer Family Registry, we compared the proportion of childhood cancers...
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