Article
Role of allelic variants of FK506-binding protein 51 (FKBP5) gene in the development of anxiety disorders.
Depression and anxiety - 1 Dec 2013
Minelli Alessandra, Maffioletti Elisabetta, Cloninger Claude Robert, Magri Chiara, Sartori Riccardo, Bortolomasi Marco, Congiu Chiara, Bignotti Stefano, Segala Matilde, Giacopuzzi Mario, Gennarelli Massimo
Abstract excerpt
BACKGROUND: Anxiety disorders exhibit remarkably high rates of comorbidity with major depressive disorder (MDD). Mood and anxiety disorders are considered stress-related diseases. Genetic variations in the co-chaperone FK506-binding protein 51, FKBP5, which modulates the function of glucocorticoid receptors, have been associated with an increased risk for the development of posttraumatic stress disorder, but data...
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