Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Administration of 4-(α-L-rhamnosyloxy)-benzyl isothiocyanate delays disease phenotype in SOD1(G93A) rats: a transgenic model of amyotrophic lateral sclerosis.

BioMed research international - 1 Jan 2015

Galuppo Maria, Giacoppo Sabrina, Iori Renato, De Nicola Gina Rosalinda, Bramanti Placido, Mazzon Emanuela

Abstract excerpt

4-(α-L-Rhamnosyloxy)-benzyl glucosinolate (glucomoringin, GMG) is a compound found in Moringa oleifera seeds. Myrosinase-catalyzed hydrolysis at neutral pH of GMG releases the biologically active compound 4-(α-L-rhamnosyloxy)-benzyl isothiocyanate (GMG-ITC). The present study was designed to test the potential therapeutic effectiveness of GMG-ITC to counteract the amyotrophic lateral sclerosis (ALS) using SOD1tg...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotransformation
Share to Glycoside Hydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Isothiocyanates

Share to Mutant Proteins

Share to Rats, Sprague-Dawley

Share to Rats, Transgenic

Share to Rhamnose

Share to Superoxide Dismutase

Source

Open in PubMed Open full text

Identifiers

PMID: 26075221
DOI: 10.1155/2015/259417
PMCID: PMC4436451

Genes

SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Administration of 4-(α-L-rhamnosyloxy)-benzyl isothiocyanate delays disease phenotype in SOD1(G93A) rats: a transgenic model of amyotrophic lateral sclerosis.PMID 26075221Read ↗

Bromocriptine methylate suppresses glial inflammation and moderates disease progression in a mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

The effect of epigallocatechin gallate on suppressing disease progression of ALS model mice.Semantic proximity Read ↗

The nutritional significance, biosynthesis and bioavailability of glucosinolates in human foodsSemantic proximity Read ↗

Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1G93A Mice.Semantic proximity Read ↗

Tempol moderately extends survival in a hSOD1(G93A) ALS rat model by inhibiting neuronal cell loss, oxidative damage and levels of non-native hSOD1(G93A) forms.Semantic proximity Read ↗

Dose-Dependent Role of a New Biotin Compound in Hippocampal Demyelination in RatsSemantic proximity Read ↗

Glycoursodeoxycholic acid reduces matrix metalloproteinase-9 and caspase-9 activation in a cellular model of superoxide dismutase-1 neurodegeneration.Semantic proximity Read ↗

Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis.Semantic proximity Read ↗

Effect of rosmarinic acid in motor dysfunction and life span in a mouse model of familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Ablation of keratan sulfate accelerates early phase pathogenesis of ALS.Semantic proximity Read ↗

[Implications of successful immunotherapy in ALS model mice].Semantic proximity Read ↗

Preclinical testing of potential therapeutics for Amyotrophic Lateral SclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.