Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Implications of successful immunotherapy in ALS model mice].

Brain and nerve = Shinkei kenkyu no shinpo - 1 Jun 2008

Urushitani Makoto

Abstract excerpt

Recent progress in clinical genetics has explored various mutations or associated genes in both familial and sporadic amyotrophic lateral sclerosis (ALS). Mutations in superoxide dismutase 1 (SOD1) account for 20% of familial ALS, and mutant SOD1 transgenic mice are still regarded as the best ALS...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Antibodies
Share to Chromogranins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forecasting

Share to Immunotherapy

Share to Motor Neurons

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 18567360

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18567360-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Implications of successful immunotherapy in ALS model mice].PMID 18567360Read ↗

[Future perspectives of immunotherapy against ALS].Semantic proximity Read ↗

[Immunotherapy Against Misfolded Proteins in ALS].Semantic proximity Read ↗

Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice.Semantic proximity Read ↗

Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS.Semantic proximity Read ↗

Therapeutic tools for familial ALS.Semantic proximity Read ↗

Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis.Semantic proximity Read ↗

Targeting of monomer/misfolded SOD1 as a therapeutic strategy for amyotrophic lateral sclerosis.Semantic proximity Read ↗

Protein misdirection inside and outside motor neurons in Amyotrophic Lateral Sclerosis (ALS): a possible clue for therapeutic strategies.Semantic proximity Read ↗

Neuronal over-expression of chromogranin A accelerates disease onset in a mouse model of ALS.Semantic proximity Read ↗

Trimeric superoxide dismutase 1 antibody as a universal biomarker for ALSSemantic proximity Read ↗

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Accumulation of Misfolded SOD1 in Dorsal Root Ganglion Degenerating Proprioceptive Sensory Neurons of Transgenic Mice with Amyotrophic Lateral SclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.