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Article

Effect of rosmarinic acid in motor dysfunction and life span in a mouse model of familial amyotrophic lateral sclerosis.

Journal of neuroscience research - 1 Mar 2010

Shimojo Yosuke, Kosaka Kunio, Noda Yoshihiro, Shimizu Takahiko, Shirasawa Takuji

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a late-onset progressive neurodegenerative disease affecting motor neurons. About 2% of patients with the disease are associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1). The purpose of this study is to assess the effect of rosemary extract and its major constituents, rosmarinic acid (RA) and carnosic acid (CA), in human SOD1 G93A transgenic...

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Identifiers

PMID: 19798750
DOI: 10.1002/jnr.22242

Genes

SOD1

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