Article
Hyperactivity and impaired attention in Gamma aminobutyric acid transporter subtype 1 gene knockout mice.
Acta neuropsychiatrica - 1 Dec 2015
Chen Long, Yang Xiaobo, Zhou Xiaoyong, Wang Cuicui, Gong Xue, Chen Biqin, Chen Yinghui
Abstract excerpt
OBJECTIVES: Attention-deficit hyperactivity disorder (ADHD) is a common neurobehavioural disorder. It is conceivable that Gamma aminobutyric acid (GABA) neurotransmission is implicated in the pathophysiology of ADHD. This study investigated the effect of GABA transporter 1 (GAT-1) on the anxiety-like behaviours and cognitive function in knockout mice. METHODS: In all, 20 adult male mice were divided into two...
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